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Scanning Probe Microscope based Tools for NanoTechnology
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Application Notes

Science & Technology Applications: Life Sciences (Biology, Biotechnology): Blood cells study.: Virus-cell Interaction: Membrane Structure

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Virus-cell Interaction

Change of the shape

Membrane Structure

Viral Particles on Membrane



Membrane Structure.

We examined simultaneously fine membrane structure and deformation.

 

a)

b)

c)

Fig. 1 (a, b, c)

a – control sample. The membrane has classical structure that was described previously [1,2]. Fine net features can be interpreted as a spectrin membrane skeleton [1].
b – damages on  rhesus monkey erythrocytes membrane after addition of canine parvovirus.
c – clusters on the edge of erythrocytes. These structures are frequently observed on erythrocytes after their interaction with viruses. They are not observed on native cells. We cannot explain their nature yet. Parallelism of lines suggests their artificial origin and relation to the scanning process, however, the angle between the parallel structures in clusters and the scanning direction changes from cell to cell.

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