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Viral Particles on Membrane |
Viral Particles on Membrane.
Viral particles can be imaged on the surface of RBC when virus-erythrocyte reaction is absent or very slow.
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Fig. 1 (a, b)
a and b – images of influenza virus particles on the surface of a chicken erythrocyte obtained simultaneously in HIGH (a) and MAG (b) mode. We can see the advantage of ERROR MODE (MAG) for studying small details (20 nm high virus particles) on an abrupt slope of erythrocyte surface (about 1 mkm high). MAG mode shows the whole surface of the erythrocyte while HIGH mode shows only a part of the cell surface that is located between two horizontal sections. Artifacts in the right low corner of the MAG-image are caused by the probe excitation during scanning. The outlines of virions extended in the same direction are caused by the form of the tip used (influenza virions have spherical form).
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